What characterizes the activation receptors?
The activation receptors lack ITIMs and frequently contain a charged cytoplasmic residue that facilitates association with transmembrane signaling chains, such as DAP12 (DNAX activating protein of 12 kd, also known as KARAP, killer activation receptor associated protein) that contains immunoreceptor tyrosine-based activation motifs (ITAMs). Such signaling chains are required for optimal expression of the receptor and signal transduction in a manner analogous to the antigen signaling complexes of T and B cells.
