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What causes the trifunctional protein enzyme group to be absent or not working properly?

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What causes the trifunctional protein enzyme group to be absent or not working properly?

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Genes tell the body to make various enzymes. People with TFP deficiency have a pair of genes that do not work correctly. Because of the changes in this pair of genes, the TFP enzymes either do not work properly or are not made at all.

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