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What causes the problem of rheumatoid arthritis?

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What causes the problem of rheumatoid arthritis?

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My grandmother is having Rheumatoid arthritis. Last week her pain increased to double fold and her doses are doubled and some new medicines are also added in her list of medicines to be taken by her every day. It is said that there are no better medicines available for the treatment of Rheumatoid arthritis. Why don’t the researchers find new and good drugs for the treatment of Rheumatoid arthritis?

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