What causes synovial sarcoma?
The exact cause of synovial sarcoma is not entirely understood, however, studies have indicated that genetic alterations may play a role in the formation of soft tissue sarcomas. Researchers have studied a small number of families that contain several members of one generation who have developed soft tissue sarcomas. In addition, limited studies have shown a possible link between soft tissue sarcomas and the development of other types of cancer. In synovial sarcoma, a rearrangement in the chromosome material between chromosomes X and #18 is usually present. This rearrangement changes the position and function of genes, causing a fusion of genes referred to as a “fusion transcript.” Patients have an abnormal fusion transcript involving two genes which creates a novel (new) gene. This important discovery has led to improvements in diagnosing rhabdomyosarcoma, and may lead to newer treatments in the future. Certain inherited diseases are also associated with an increased risk of developin
