What causes renal cell carcinoma (cancer of the kidney)?
The exact cause of renal cancer has not been determined. A number of different factors may contribute to advanced renal cell cancer such as family history or genetic predisposition, smoking, occupational exposure to toxic compounds, obesity, polycystic kidney disease, Von Hippel-Lindau (VHL) disease or hereditary papillary renal cell carcinoma, or misuse of certain pain medicines.