What causes megaloblastic (pernicious) anemia?
Megaloblastic (pernicious) anemia is more common in individuals of northern European descent. Megaloblastic (pernicious) anemia results from a lack of intrinsic factor in gastric secretions (a substance needed to absorb vitamin B12 from the gastrointestinal tract). Vitamin B12 deficiency results. The inability to make intrinsic factor may be the result of chronic gastritis, or the result of a gastrectomy (removal of all or part of the stomach). Megaloblastic (pernicious) anemia may also be associated with type 1 diabetes, thyroid disease, and a family history of the disease. What are the symptoms of megaloblastic (pernicious) anemia? The following are the most common symptoms for megaloblastic (pernicious) anemia. However, each individual may experience symptoms differently. Symptoms may include: • weak muscles • numbness or tingling in hands and feet • difficulty walking • nausea • decreased appetite • weight loss • irritability • lack of energy or tiring easily (fatigue) • diarrhea •
