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What causes MDS/MPD?

April 26, 2017causes MDs MPD

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What causes MDS/MPD?

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While patients with MDS/MPD lack the Philadelphia chromosome that is common to chronic myeloid leukemia (CML), chromosomal damage is common in patients with this disease, including gene rearrangements involving the platelet-derived growth factor receptor gene known as PDGFR. The new gene resulting from this kind of rearrangement produces an abnormal protein that adversely impacts normal cellular processes, causing cells to multiply out of control.