What causes large platelets and hypersegmented neutrophils?
Neutrophils are white cells in the blood that help fight infection and normally have 4 lobes or segments. Any neutrophil that has more than 6 lobes is considered hypersegmented. Hypersegmented neutrophils can occur with vitamin B12 deficiency, Folate Deficiency and Myelodysplastic syndrome. http://en.wikipedia.org/wiki/Hypersegmen… Platelets are the cells in the blood that group together to form a blood clot. Large platelets can be secondary to some rare genetic disorders, such as Bernard-Soulier syndrome, Gray platelet syndrome), and the May-Hegglin anomaly. Enlarged platelets can also be secondary to Myelodysplastic syndrome or autoimmune destruction of platelets. It has no relation to hypersegmented neutrophils. It is difficult to interpret these abnormalities without knowing your mother’s medical history. If she is concerned about these, then she should discuss this with her doctor who knows all the
