What causes CLL?
CLL is caused by an acquired (not inherited) injury to the DNA of a single cell in the bone marrow which becomes abnormal. The result is the uncontrolled growth of lymphocytic cells in the bone marrow and an increase in the concentration of lymphocytes in the blood. Unlike other forms of leukemia, CLL is not connected to high-dose radiation or benzene exposures. Although CLL is not hereditary, the disease does seem to run in families, and the risk increases with age. According to the American Cancer Society, research studies suggest that chemicals used in farming (such has herbicides and insecticides) and Agent Orange (an herbicide used during the Vietnam War) may increase the risk of CLL. How is CLL diagnosed? The symptoms of CLL, which usually develop gradually, include tiring easily and shortness of breath when physically active. The patient may lose weight and have frequent infections of the skin, lungs, and kidneys. There may be a feeling of pain or fullness in the belly (especial