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What causes children with Alagille syndrome to develop xanthomas?

April 26, 2017alagille causes children develop SYNDROME xanthomas

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What causes children with Alagille syndrome to develop xanthomas?

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The severe high cholesterol in AGS leads to cholesterol depositions in the skin. In children with Alagille syndrome, spontaneous improvement in bile flow often occurs in children after 3 years of age and this leads to a reduction in lipids and xanthomas.