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What are viral particle (VP), plaque formation unit (PFU), and infectious unit (IFU)?

April 26, 2017FORMATION ifu particle pfu plaque viral VP

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What are viral particle (VP), plaque formation unit (PFU), and infectious unit (IFU)?

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Viral particles (VPs) represent the total number of viral particles (infectious and infection-deficient combined). Due to variations in virus preparations, the ratio of infectious /non-infectious varies significantly and therefore, VP does not reflect the concentration of virus in a preparation. PFU ( plaque forming unit) represents the number of infectious or live viruses. It reflects the concentration of infectious viruses in a preparation. IFU (infectious unit) is biologically equivalent to PFU. For most virus preps, the VP/PFU ratio is 20:1 to 50:1.