What are the warning signs of a bad reaction to Prempro?
Warning symptoms include mental/mood changes; e.g., severe depression, memory loss, calf pain/swelling, sudden severe headache, chest pain, trouble breathing, one-sided weakness, slurred speech, vision changes, swelling of hands and feet, changes in vaginal bleeding; e.g., spotting, breakthrough bleeding or prolonged bleeding, unusual vaginal discharge/itching/odor, and yellowing of the eyes or skin (jaundice).
