What are the uncertainties and limitations to using a screening-level assessment to evaluate what detections may mean to human health?
Uncertainties are associated with screening-level assessments such as used in this study. Specifically, concentrations less than human-health benchmarks, such as USEPA Maximum Contaminant Levels (MCLs) and USGS Health-Based Screening Levels (HBSLs), indicate that adverse effects are unlikely to occur, even if water with such concentrations were to be ingested over a lifetime. Water containing concentrations greater than these benchmarks might be of potential human-health concern if the water were to be ingested as the primary drinking-water source without treatment for many years. The likelihood for adverse effects generally increases as concentrations increase above their benchmark values. If water containing concentrations greater than their benchmarks is ingested, however, it does not mean that adverse human-health effects will occur because: (1) human-health benchmarks are intentionally conservative (protective) and incorporate safety factors and conservative assumptions to account
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