What are the Treatments for Cushings?
Lysodren (o,p’-DDD or Mitotane) is the most commonly prescribed drug for treating Cushing’s Disease (Pituitary Dependent Hyperadrenocorticism). It works by destroying the outer layer of the adrenal glands (adrenal cortices), thus limiting their ability to produce cortisol in response to the ACTH signals of the hyperactive pituitary gland. Loading Dose. Treatment begins with a “Loading Dose” of Lysodren. The dog is given a large, daily or twice daily dose of Lysodren until a response is seen. The typical response begins with a diminished water intake and/or a diminished appetite, but can also include diarrhea, vomiting, and lethargy. The typical loading period is 6 to 9 days, however, it is crucial that the owner monitor the dog’s water and food consumption and observe the dog’s behavior as it is possible for the dog to have an extreme response which requires the intervention of a veterinarian. Often, the monitoring vet will prescribe prednisone to keep on hand in case of an extreme rea
