What are the signs of plague infection in humans?
Clinical signs in humans usually develop within 2 to 8 days of infection and include sudden onset of headache, fever, chills, and weakness. An acutely swollen and painful lymph node (bubo) often appears approximately 24 hours after the start of clinical signs. Some individuals may develop septicemia without a bubo (primary septicemic plague) or septicemia may occur secondary to bubonic plague. Gangrene (hence the name “black death”), coagulopathies, and multiple organ failure may result from advanced plague septicemia.
