What are the side effects of oral bisphosphonates?
The trials of tablet bisphosphonates show a low rate of stomach upset, not different in those treated as compared to those not treated. Nevertheless, there are people who do not tolerate bisphosphonate tablets due to stomach side effects. Often it is difficult to know whether stomach upset is from the osteoporosis tablet or from heartburn that might have occurred without the medication. Others with difficulty swallowing pills, unable to sit up after dosing, or with a disease interfering with absorption may not be suitable for tablet bisphosphonate therapy. In these cases, intravenous bisphosphonate offers the benefits of bisphosphonate therapy to patients without the possibility of stomach side effects. In addition, patients taking many medications, or diabetics unable to delay breakfast, may also benefit from an intravenous bisphosphonate.
