What Are the Side Effects from Standard NSAIDs?
Most people who use NSAIDs don’t have any serious problems with them. But in some — especially those who need pain relief regularly — there can be a downside. When you swallow a pill, it affects your whole system, not just the part that hurts. So while an NSAID may do a great job of easing your pain, it may also be having other effects — some of them unwanted — in other parts of your body. • Gastrointestinal Problems The most common risk of standard NSAIDs is that they can cause ulcers and other problems in your esophagus, stomach, or small intestine. Why? NSAIDs prevent the creation of prostaglandins, the hormone-like chemicals that cause swelling and increase pain. But that’s not all that prostaglandins do. There are actually many different types of prostaglandins in your body. One type of prostaglandin helps protect the lining of the stomach and GI tract. And the Cox-1 enzyme helps make this prostaglandin. Since regular NSAIDs block Cox-1 enzymes, they slow down the manufacture
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