What are the side effect of melatonin?
Melatonin is practically nontoxic and exhibits almost no toxic side effects, except for the occurrence of somnolence in most of the population at higher doses. Exogenous melatonin normally does not affect the endogenous melatonin profile in the short or medium-term. However, melatonin taken in combination with monoamine oxidase inhibitors (MAOIs) can lead to overdose because MAOIs inhibit the breakdown of melatonin by the body. Individuals who experience orthostatic intolerance, a cardiovascular condition that results in reduced blood pressure and blood flow to the brain when a person stands, may experience a worsening of symptoms when taking melatonins supplements, a study at Penn State College of Medicine’s Milton S. Hershey Medical Center suggests. Melatonin can exacerbate the symptoms by reducing nerve activity in those who experience the condition, the study found. Melatonin has been associated with a worsening of autoimmune disorders, and its use by those suffering multiple scler
