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What are the risks associated with iPS cell use in humans?

April 26, 2017associated CELL humans iPS

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What are the risks associated with iPS cell use in humans?

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The retroviruses used in the generation of iPSc are associated with cancer because they insert DNA anywhere in a cell’s genome, which could potentially trigger the expression of cancer-causing genes. Another risk associated with iPS cell technology applied to humans is the fact that c-Myc, which is one of the genes used in reprogramming, is a known oncogene whose overexpression could also cause cancer.