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What are the problems associated with the long term use of orally administrated Cox-2 inhibitors?

April 26, 2017administrated associated cox-2 Inhibitors orally problems term

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What are the problems associated with the long term use of orally administrated Cox-2 inhibitors?

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Long-term use of orally administrated Cox-2 inhibitors is now associated with a higher risk of strokes and heart attacks because of their systemic characteristics.