What are the primary strategies for eliminating, reducing and managing conflicts of interest?
The 2003 Guidance states: “financial interests may be managed by eliminating them or mitigating their potentially negative impact.” The primary strategies for managing conflicts of interest are disclosure and prohibition. A number of influential professional societies, researchers and institutions have advocated a total ban on paid consultancies and equity holdings in entities related to their research; some have recommended barring investigators from investments in fields in which they are conducting research. Less drastic approaches include: • peer review of the study design • independent oversight of the research • insulating investigator from knowledge about the impact of financial interests through blind-trust type devices • insulating the subject/participant from the influence of financial considerations on professional judgment by having an investigator with a conflict abstain from problematic aspects of the study • disclosure of the financial interest to subjects on the consent
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