What are the possible side effects of Prempro?
Menstrual periods beginning again, including changing menstrual bleeding pattern for up to 6 months (spotting, breakthrough bleeding, prolonged or heavier vaginal bleeding, or vaginal bleeding completely stopping by 10 months); vaginal itching or irritation, or thick, white vaginal discharge. Less common side effects include sharp chest or lower leg (calf) pain, breast lumps, severe headache, shortness of breath, coughing up blood, severe stomach pain or swelling, abnormal vaginal bleeding, mild dizziness, nausea and fluid retention. Other, more serious risks associated with Prempro, are discussed elsewhere.
