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What are the possible side effects of estradiol vaginal (systemic)?

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What are the possible side effects of estradiol vaginal (systemic)?

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Remove the vaginal ring and seek emergency medical attention if you have fever with nausea, vomiting, diarrhea, muscle pain, dizziness, fainting, and/or sunburn-like skin rash. These may be signs of a life-threatening disease called toxic shock syndrome.

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