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What are the possible side effects of estradiol (Estrace Vaginal Cream, Estring)?

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What are the possible side effects of estradiol (Estrace Vaginal Cream, Estring)?

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Estradiol increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, while using estradiol lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together while using estradiol. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with estradiol long-term…

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