What are the Negative Side Effects of Statin Drugs?
Adverse effects of Statin Statins are generally perceived[28] as well-tolerated. The most common adverse side effects are raised liver enzymes and muscle problems. In clinical trials, reported adverse effects are low; but “higher in studies of real world use”, and more varied.[28] Statins increased the risk of an adverse effect by 39% compared to placebo (odds ratios 1.4); two-thirds of these were myalgia or raised liver enzymes with serious adverse effects similar to placebo.[29] Some patients on statin therapy report myalgias,[30] muscle cramps,[30] or, less frequently, gastrointestinal or other symptoms. Similar symptoms are also reported with placebo use in all the large statin safety/efficacy trials and usually resolve, either on their own or on temporarily lowering/stopping the dose[citation needed]. Liver enzyme derangements may also occur, typically in about 0.5%,[citation needed] are also seen at similar rates with placebo use and repeated enzyme testing, and generally return
