What are the most severe risks of vaccination BOTH to vaccinees (i.e. the persons who receive the vaccine) and to their contacts?
The most complete nationwide vaccine safety data in the USA came from a national survey of all 50 states in 1968 (a subset of only 10 states were also surveyed in a different study in 1968 that used a different form of surveillance (more active) (for this data see Breman and Henderson NEJM April 25, 2002). The 50 state, nationwide survey found: Deaths: 9 vaccinees died out of 14 million who received vaccine in 1968. Other statistically rare, but severe adverse reactions to the vaccine included: Encephalitis: 16 persons/14 million vaccinees (all 16: first-time vaccinees). Progressive vaccinia— necrosis of skin or muscle: 11 persons /14 million in 1968. Eczema vaccinatum (can occur if a vaccinee or a contact of a vaccinee ever had a history of eczema): 66 vaccinees/14 million AND in another 60 persons with a history of eczema who were contacts of vaccines. Generalized vaccinia: 141 vaccinees/14 million AND 2 contacts. Note: Additional data on severe and mild (e.g., rash and lymphadenop
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