What are the mechanisms of PPAR-gamma-inhibiting pancreatic carcinoma growth?
Peroxisome proliferator-activated receptor gamma (PPAR-gamma), a member of the family of ligand-activated nuclear receptor transcription factors, is expressed in many human solid tumors. It was reported that activation of PPAR-gamma can inhibit the growth of pancreatic carcinoma cells, colon cancer cells, gastric cancer cells and liposarcoma cells. Some in vitro studies have recently reported that PPAR-gamma activation has inhibitory effects on the growth of pancreatic carcinoma cells, probably due to its up-regulation of cellular apoptosis and its down-regulation of tumor invasion. However, little attention has previously been paid to PPAR-gamma action on the growth of pancreatic carcinoma in vivo, especially its possible mechanisms. A research team led by Dr. Xing-Peng Wang from China address this question. Their study will be published on January 28, 2009 in the World Journal of Gastroenterology. In their study, Expressions of PPAR-gamma and retinoid acid receptor (RXR-alpha) were e
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