What are the main disadvantages of synthetic base oils over mineral base oils?
The main disadvantage of synthetic lubricants is that they are inherently more expensive than mineral oils, and are limited in supply. This limits their use to speciality oils and greases that command premium prices. Esters suffer further disadvantage of greater seal-swelling tendencies than hydrocarbons: so, caution has to be exercised in using them in applications where they many contact elastomers designed for use with mineral oils.