What are the long-term risks of Depo-Provera on bone mineral density (BMD)?
There is conflicting evidence regarding the association of bone loss and Depo-Provera. Four cross-sectional studies have reported a significant decrease in the BMD among Depo-Provera users. However, other research studies have failed to show any difference between users and nonusers. It is clear that a randomized controlled trial is needed to ascertain the effects of long term Depo-Provera on BMD. Until further studies are available caution should be taken when prescribing Depo-Provera to women with other risk factors for osteoporosis. Women can also be reassured that the observed bone loss in the studies claiming concern did not fall into the osteoporotic range and the lost bone was recovered when the Depo-Provera was discontinued.
