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What are the indications for VZIG use?

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What are the indications for VZIG use?

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The Advisory Committee on Immunization Practices and the American Academy of Pediatrics (AAP) indicate that the decision to administer VZIG to a person exposed to varicella-zoster virus (VZV) should be based on whether a) the patient is susceptible (either by having a negative history of varicella or by lacking documentation of vaccination), b) the exposure is likely to result in infection, and c) the patient is at greater risk for severe disease and complications than the general population. (http://www.cdc.gov/mmwr/preview/mmwrhtml/00042990.htm). Several types of exposure can place susceptible persons at risk for varicella. Direct contact exposure is defined as greater than 1 hour of direct contact with an infectious person while indoors; substantial exposure for hospital contacts consists of sharing the same hospital room with an infectious patient or prolonged, direct, face-to-face contact with an infectious person (e.g., health-care workers). Brief contacts with an infectious pers

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