What are the harms associated with testing for CYP450 polymorphisms and subsequent management options?
We also developed a project-specific analytic framework that provides an explicit link between CYP450 testing and various health outcomes of importance to decisionmakers. We searched MEDLINE® (1966-May 2006), the Cochrane Database of Abstracts of Reviews of Effects (DARE), PsychInfo, HealthSTAR, and CINAHL. Searches of these databases were supplemented by reviews of the reference lists contained in all included articles and in relevant review articles. Documents from the FDA that could be publicly accessed were also included. The searches yielded a total of 1,200 citations. Pairs of researchers independently reviewed each abstract and selected 140 for full-text review. Project-specific inclusion/exclusion criteria were developed, and both researchers were required to agree on inclusion status at the full-text stage. A total of 37 articles were included for data abstraction. Evidence tables were developed, and data abstraction was carried out by one investigator and checked for accuracy
