What are the genetic changes related to triple X syndrome?
Triple X syndrome is related to the X chromosome. People normally have 46 chromosomes in each cell. Two of the 46 chromosomes are sex chromosomes, called X and Y. Females have two X chromosomes (46,XX), and males have one X chromosome and one Y chromosome (46,XY). Triple X syndrome results from an extra copy of the X chromosome in each of a female’s cells. As a result of the extra X chromosome, each cell has a total of 47 chromosomes (47,XXX) instead of 46. It remains uncertain why an extra copy of the X chromosome is associated with tall stature and learning problems in some girls and women. Some females with triple X syndrome have an extra X chromosome in only some of their cells. These cases are called 46,XX/47,XXX mosaics. Read more about the X chromosome.