What are the genetic changes related to nonsyndromic deafness?
Nonsyndromic deafness is a condition related to changes in mitochondrial DNA. Mutations in the ACTG1, CDH23, CLDN14, COCH, COL11A2, DFNA5, DFNB31, DFNB59, ESPN, EYA4, GJB2, GJB6, KCNQ4, LHFPL5, MT-TS1, MYO15A, MYO6, MYO7A, OTOF, PCDH15, POU3F4, SLC26A4, STRC, TECTA, TMC1, TMIE, TMPRSS3, TRIOBP, USH1C, and WFS1 genes cause nonsyndromic deafness. Variations of the MT-RNR1 gene increase the risk of developing nonsyndromic deafness. Variations in the ATP2B2 gene modify the course of nonsyndromic deafness. The GJB3 and MYO1A genes are associated with nonsyndromic deafness. The causes of nonsyndromic deafness are complex. Researchers have identified more than 30 genes that, when mutated, may cause nonsyndromic deafness; however, some of these genes have not been fully characterized. Many genes related to deafness are involved in the development and function of the inner ear. Mutations in these genes result in hearing loss by interfering with critical steps in processing sound. Different muta
