What are the external stimuli and when are they actually needed?
External stimuli are the inductive factors that trigger the cell machinery into replication/expansion of precursor cell populations and influence β-cell differentiation. In pancreatectomy, for instance, tissue injury induces a response to stimulate tissue healing and cellular regeneration. As is evident from current literature, the regeneration of any organ is a process where cells of varied lineages and undecided and decided cell fates together compensate for the lost cell mass. However, the existing sources of cell mass maintenance are inadequate to justify the regeneration of an entire organ in vivo. Hence it appears plausible to assume the presence of a yet unidentified stem cell population, which we would like to call naive precursor cells (NPC). These NPC may possess functional plasticity and replicative capacity to respond to appropriate stimulation, helping in regeneration to compensate for the lost β-cell mass. There are studies where the presence of similar types of cell popu
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