What are the dose modification recommendations for Avastin?
Permanently discontinue Avastin in patients with GI perforation (GI perforation, fistula formation in the GI tract, intra-abdominal abscess), wound dehiscence requiring medical intervention, serious bleeding, fistula formation involving an internal organ, severe ATE, nephrotic syndrome, hypertensive crisis, or hypertensive encephalopathy. In patients developing RPLS, discontinue Avastin and initiate treatment of hypertension if present. Symptoms usually resolve or improve within days, although some patients have experienced ongoing neurologic sequelae. The safety of reinitiating Avastin therapy in patients previously experiencing RPLS is not known. Temporary suspension is recommended in patients with evidence of moderate to severe proteinuria and in patients with severe hypertension that is not controlled with medical management. The risk of continuation or temporary suspension of Avastin in patients with moderate to severe proteinuria is unknown. Avastin should be suspended for at lea
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- What are the dose modification recommendations for Avastin?
