What are the diseases associated with HLA?
• HLA molecules play a central role in the immune response. They are so polymorphic that the HLA type individualizes a person’s immune response and, therefore, is associated with the person’s susceptibility to several autoimmune and auto-inflammatory diseases. These diseases are usually polygenic and triggered or influenced by environmental factors; therefore, a person’s HLA type is only one component of his/her susceptibility towards the disease. Some of the most common associations are listed below: HLA-B27 Ankylosing spondylitis, acute anterior uveitis HLA-DQ2, 8 Celiac disease HLA-DR15, DQ6 Narcolepsy HLA-DR3, 4 Diabetes HLA-DR4 Rheumatoid arthritis Certain HLA-disease associations are commonly used for diagnosis. We have established specific test codes for them and indicate the diagnostic use in the test name. We perform the same tests as those listed for intermediate resolution typing, but the physician does not need to specify the locus or allele when ordering. Additionally, we
