What are the disadvantages of topiramate?
As topiramate has only been available for a relatively short time, it was first marketed in 1996, there is no information about long term side-effects. As its use with people with mood disorders started even more recently, it is not known if people who initially do well on topiramate continue to do so after many years of treatment. Topiramate increases the probability of kidney stones. the development of kidney stones may be prevented by increasing one’s intake of water.