What are the disadvantages of bisphosphonate (Fosamax, Boniva, etc) therapy?
Bisphosphonates work by killing osteoclasts, or the body’s natural cells that promote turnover and remodeling of bone. So, new bone is laid down over old bone. This increases bone density, but many feel it is at the expense of increased bone fragility. In fracture patients, this is a problem because fractures heal best with your body turns over bone naturally.
