What are the different types of dystrophic EB (DEB)?
Dystrophic EB (DEB) is found equally in males and females. There are two types of inheritance in dystrophic EB. These are called dominant and recessive: Dominant dystrophic EB (DDEB) Everyone has two copies of every gene, one inherited from their mother and one from their father. In DDEB a defect in one of those genes can lead to fragile skin and blistering, even though the other gene is normal. This means anyone who has DDEB can pass the condition onto his or her children. Each time a pregnancy occurs, there is a 1 in 2 chance that the child will inherit DDEB, if one parent is affected. However, DDEB can sometimes be seen as a ‘new mutation’ when there is no family history. Recessive dystrophic EB (RDEB) In RDEB both copies of the gene have to be defective in order for the person to have fragile skin and blisters. A person with one defective copy of the gene is healthy and is said to be a carrier of the disorder. However, if two such people who carry a defective copy have children, th
