WHAT ARE THE DIFFERENT FORMS OF SMA?
The disease has a wide range of impact on children. Common forms of childhood- or juvenile-onset SMA are: Type I Acute SMA (Werdnig-Hoffmann Disease): Affects the respiratory or breathing muscles of infants in the womb or shortly after birth. Victims typically exhibit limited movement and have difficulty holding their head straight, feeding and swallowing. Reduced strength in the chest muscles often results in labored breathing with the chest appearing sunken. The progressive weakening of the muscles leads to respiratory infections and eventual death, usually by the age of two. More than 50% of patients with SMA have this form of the disease. Type II Intermediate SMA: Symptoms usually emerge in patients between six and eighteen months, and the progression of symptoms varies greatly. Muscle weakness and respiratory infections are typical. Infants and children with this form of the disease are at one time able to sit independently. Due to the varied progression of symptoms, life expectan
The disease has a wide range of impact on children. Common forms of childhood-onset SMA are: Type I Acute SMA (Werdnig-Hoffman Disease): Affects the bulbar muscles of infants in the womb or shortly after birth. Victims typically exhibit limited movement, and difficulty holding their head straight, feeding and swallowing. Reduced strength in the chest muscles often results in labored breathing with the chest appearing sunken. The progressive weakening of the muscles leads to respiratory infections and eventual death, usually by the age of two. Type II Intermediate SMA: Symptoms usually emerge from six months through age two, and the progression of symptoms varies greatly. Muscle weakness and respiratory infections are typical. Due to the varied progression of symptoms, life expectancy ranges from early childhood to adulthood. Type III Mild SMA (Kugelberg-Welander or Juvenile Spinal Muscular Atrophy): Symptoms appear between two and 17 years of age. Those afflicted can often exhibit diff
spinal muscular atrophy (SMA) is the name given to a group of inherited diseases http://www.muscle.ca/content/index.php?id=993 • Spinal Muscular Atrophy, Dandy-Walker Complex, And Cataracts In Two Siblings: A University of Athens, 74 Vas. Sofias Avenue, Athens 11528, Greece; mpanas@med.uoa.gr. Keywords DandyWalker; cataracts; spinal muscular atrophy http://jnnp.bmjjournals.com/cgi/content/extract/76/8/1183 Extractions: This Article Full Text Full Text (PDF) Submit a response … Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal … Download to citation manager PubMed PubMed Citation Articles by Panas, M Articles by Markomichelakis, N Related Collections Other Neurology • Clinical And Molecular Diagnosis Of Spinal Muscular Atrophy. Panigrahi I, Kesari Neurol India is an peerreviewed biomedical periodical of Neurological Society of India. http://www.neurologyindia.com/a
