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What are the differences between viral particle (VP) and plaque formation unit (PFU)?

April 26, 2017differences FORMATION particle pfu plaque viral VP

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What are the differences between viral particle (VP) and plaque formation unit (PFU)?

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A. Viral particles (VPs) represent the total number of viral particles (live and dead combined). Because of variations in viral preparations the ratio of live/dead varies significantly. Thus, VP doesnt reflect the amount of live virus in the preparation. PFU (plaque formation unit) represents the number of infectious or live viruses. It reflects the amount of working viruses in the preparation. For most virus preps, the VP/PFU ratio is 20:1 to 50:1.