What are the differences between intravenous and oral bisphosphonates?
The major difference in bisphosphonates is in the way in which they are given (into the vein or oral) and the interval between doses. Different bisphosphonate medications may have different abilities to prevent fractures and may have different side effects. Intravenous bisphosphonates are 100% absorbed. Oral bisphosphonates are poorly absorbed, with at best 1% to 3% of the tablet dose being absorbed. Dosing must be 30 to 60 minutes before breakfast, with just water and with delay of first food or drink until at least 30 minutes have passed. An important aspect of using medications for osteoporosis is whether the patient is willing to continue on long-term treatment. Many patients prefer taking their bisphosphonate at longer intervals. The longest interval dosing available is with zoledronic acid annual intravenous infusion.
