What are the contraindications and warnings for the use of Argatroban?
Argatroban is contraindicated in patients with overt major bleeding, or in patients hypersensitive to Argatroban or any of its components.[2] Argatroban is intended for intravenous administration.[2] All parenteral anticoagulants should be discontinued before administration of Argatroban. Hemorrhage can occur at any site in the body in patients receiving Argatroban.[2] An unexplained fall in hematocrit, fall in blood pressure, or any other unexplained symptom should prompt consideration of a hemorrhagic event. Argatroban should be used with extreme caution in disease states and other circumstances in which there is an increased danger of hemorrhage. These include severe hypertension; immediately following lumbar puncture; spinal anesthesia; major surgery, especially involving the brain, spinal cord or eye; hematologic conditions associated with increased bleeding tendencies such as congenital or acquired bleeding disorders, and gastrointestinal lesions such as ulcerations.
