What are the contra-indications of LODOSYN?
LODOSYN is contraindicated in patients with known hypersensitivity to any component of this drug. Nonselective monoamine oxidase (MAO) inhibitors are contraindicated for use with levodopa or carbidopa-levodopa combination products with or without LODOSYN. These inhibitors must be discontinued at least two weeks prior to initiating therapy with levodopa. SINEMET (Carbidopa-Levodopa) or levodopa may be administered concomitantly with the manufacturer’s recommended dose of an MAO inhibitor with selectivity for MAO type B (e.g., selegiline HCl). Levodopa or carbidopa-levodopa products, with or without LODOSYN, are contraindicated in patients with narrow-angle glaucoma. Because levodopa or carbidopa-levodopa products, with or without LODOSYN, may activate a malignant melanoma, they should not be used in patients with suspicious, undiagnosed skin lesions or a history of melanoma. Please refer to the full prescribing information for more information.
