What are the common therapies for Ulcers/EGUS?
Traditionally antacids were used to decrease the discomfort and increase the pH of the stomach contents. The traditional components are usually a combination of magnesium hydroxide and aluminum hydroxide (i.e. Neighlox). The effect of even a large dose (240-360 ml) of these compounds is short lived and would require repeat dosing every 2-6 hours to have any real effect on ulcer healing (Hinchcliff et al, 2004). Additionally these compounds can reduce the absorbability of some other medications given orally. Bismuth compounds, such as Pepto Bismol have not been shown to have any significant effect at all (Picavet, 2002). Various other remedies (i.e. Papaya, Gastrex) have been used as antacid therapy in horses with variable results. Coating agents such as Sucralfate (dose range from 10-40 mg/kg) also require frequent dosing (every 6-8 hrs) to have an effect. The act by forming a protective gel-like coating over the ulcers themselves, and therefore have no direct healing effect (Robinson,
