What are the common predisposing risk factors for hepatocellular cancer?
Cirrhosis of the liver, from any cause, is a predisposing risk factor for the development of hepatocellular carcinoma. Hepatitis B, hepatitis C, and hemochromatosis are associated with a very high risk. Less common causes include alcohol abuse and anabolic steroid use. Exposure to aflatoxin, produced by the fungus Aspergillus flavus, is a major risk factor in less developed parts of the world, particularly sub-Saharan Africa. Tropical weather and sub-optimal storage of grains can lead to contamination with the fungus.
