What are the chances of identifying a non-sense or splice affected mutation in my chosen gene?
At present, we routinely screen ~500bp of coding sequence per gene across 3840 individuals, which yields ~1/3 chance of identifying a nonsense or splice-site mutation. The actual rate depends on the amino acid sequence of the protein (some have greater probability of producing to a nonsense allele with ENU mutagenesis than others).
Related Questions
- Why does a mutation that deletes one or two DNA nucleotides changes gene function more drastically than a substitution of one nucleotide for another type?
- What are the chances of identifying a non-sense or splice affected mutation in my chosen gene?
- What is a mutation in which only one nucleotide or nitrogenous base in a gene is changed?
