What are the cells taking part in host immunity? State their roles in the process of inflammation?
Natural cytolytic cells a) Natural killer cells – Large granular lymphocytes, having Fc receptors for antibodies and kill anti body coated cells and virus infected tumor cells Phagocytic cells a) Neutrophils – Granulocytes with multilobed nucleus; help in phagocytosis and kill bacteria b) Eosinophils – Granulocytes with bilobed nucleus and coarse brick-red cytoplasmic granules; take part in parasite defense and allergic response c) Macrophages – Present in tissue, spleen, lymph nodes; bears Fc and C3 receptors on cell surface; takes part in inflammatory response anti-viral and anti-tumor activities Antigen-presenting cells (APCs) a) Monocytes – agranulocytes with Horse-shoe shaped nucleus that modulates immune response by releasing various cytokines b) Macrophages – as above Antigen -responsive cells a) CD4 T cells – Mature in thymus, characterized by large nucleus, small cytoplasm; contains CD2, CD3, TCR, CD4 molecules on cell surface; Secretes IL-1 and other lymphokines and stimulate
