What are the causes of treatment-resistant depression?
Several factors may cause or contribute to treatment-resistant depression. These include: Depression severity. The more severe your depression initially is and the longer a depression episode lasts, the more likely the depression is to resist improvement with treatment and become chronic depression. • The wrong diagnosis. It’s not always easy to diagnose depression and other mental disorders. In particular, some forms of bipolar disorder are commonly misdiagnosed as depression because manic phases may be less pronounced while depression phases are more pronounced — it may look more like depression. • Other medical conditions. Other medical conditions or illnesses can sometimes mimic or worsen depression. These include thyroid disorders, chronic pain, anemia, heart problems, anxiety disorders, and substance abuse or addictions. • Your social or life situation. If you’re under constant stress or anxiety because of situations in your life that aren’t getting better, medication alone might
