What are the alternative methods of DNA vaccine delivery?
DNA vaccines have tremendous potential as preventive or therapeutic agents against cancers and infectious diseases. One of the obstacles to the successful development of DNA vaccines is the limitations associated with most DNA delivery systems. A successful DNA delivery system must be able to safely and effectively deliver the DNA vaccine into cells of targeted tissue where the DNA can subsequently achieve gene expression of the encoded protein at desired levels and for the desired duration of time. To be commercially compelling, the delivery method must be readily reproducible and low cost. One method that has shown a compelling balance of safety, efficiency, and economy in pre-clinical and initial human data is Inovio’s electroporation-based DNA delivery solution. The following table compares the main DNA carrier or delivery alternatives: What are the challenges to DNA vaccine delivery? Viral vectors (carriers) have been the most studied approach to intracellular DNA delivery. Levera
